Their diameter, in vitro release, surface charge, morphology, ex vivo permeability, pH, histological, and in vivo (pharmacokinetics and brain uptake) arguments were guessed. BER-CTS-NLCs had a size of 180 ± 4 nm, sustained-release attributes, positive surface charge of 36 mV, and augmented ex-vivo permeation via nasal mucosa. The histopathological assessment disclosed