Medications For Anxiety Disorder and Depression Medications help many people manage anxiety, but they're not the only option. Exercise and psychotherapy are effective treatments too. Certain antidepressants, including SSRIs (citalopram, Lexapro, fluoxetine, Prozac, paroxetine, Zoloft) also treat anxiety. Other medications, such as histamine blockers, such as Vistaril (hydroxyzine) can also