The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, Escitalopram, fluoxetine (Prozac), venlafaxine and duloxetine are the first-line treatments for anxiety disorders. Psychotherapy and exercise are essential for people suffering from anxiety. Antihistamines, such as hydroxyzine (Atarax Vistaril, Atarax) are prescribed by certain doctors. They work by