The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, the escitalopram drug and fluoxetine (Prozac) Venlafaxine, citalopram, and duloxetine are first-line treatments for anxiety disorders. Exercise and psychotherapy are important for people with anxiety. Antihistamines, such as hydroxyzine (Atarax, Vistaril) are prescribed by some doctors. They aid