The Best Medicine For Anxiety Disorders SSRIs and SNRIs like citalopram, Escitalopram and the fluoxetine (Prozac) Venlafaxine, citalopram and duloxetine are first-line treatments for anxiety disorders. Exercise and psychotherapy are also important for people with anxiety. Certain doctors prescribe antihistamines, such as hydroxyzine (Atarax or Vistaril). They help by blocking