The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, escitalopram, the fluoxetine (Prozac) Venlafaxine, citalopram and duloxetine are treatments of first line for anxiety disorders. Exercise and psychotherapy are also important for people with anxiety. Certain doctors prescribe antihistamines, like hydroxyzine (Atarax or Vistaril). They work by