The Best Medicine For Anxiety Disorders SSRIs and SNRIs like citalopram, escitalopram, the fluoxetine (Prozac) Venlafaxine, citalopram and duloxetine are first-line treatments for anxiety disorders. Psychotherapy and exercise are essential for those with anxiety. Certain doctors prescribe antihistamines, like hydroxyzine (Atarax or Vistaril). They help by blocking certain histamine receptors