Medications For Anxiety Disorder and Depression Medications help many people manage anxiety, but they aren't the only option. Psychotherapy and exercise can be powerful treatments too. Some antidepressants, like SSRIs (citalopram, Lexapro, fluoxetine, Prozac, paroxetine, Zoloft) also help with anxiety. Others, such as histamine blockers like Vistaril (hydroxyzine) can help