The Best Medicine For Anxiety Disorders SSRIs (selective serotonin reuptake inhibitors) and SNRIs such as citalopram (Celexa), the escitalopram (Lexapro), the fluoxetine (Prozac) duloxetine (Cymbalta) and venlafaxine (Effexor XR) are considered to be the first-line treatment for anxiety disorders. Psychotherapy and exercise are essential for those with anxiety. Antihistamines, such