The Best Medicine For Anxiety Disorders SSRIs and SNRIs like citalopram, Escitalopram, fluoxetine (Prozac) Venlafaxine, citalopram and duloxetine are treatments of first line for anxiety disorders. Psychotherapy and exercise are also essential for those suffering from anxiety. Certain doctors prescribe antihistamines, such as hydroxyzine (Atarax or Vistaril). They work by