The Best Medicine For Anxiety Disorders SSRIs and SNRIs like citalopram, the escitalopram drug and the fluoxetine (Prozac) Venlafaxine, citalopram, and duloxetine are the first-line treatments for anxiety disorders. Psychotherapy and exercise are also essential for those suffering from anxiety. Antihistamines like hydroxyzine (Atarax Vistaril) are prescribed by a few