ADHD Medication - Ritalin Ritalin (methylphenidate) is effective in managing ADHD symptoms in adults. It can make people feel "up," alert, awake, and filled with a an euphoria. ADHD medications work by altering two brain chemicals, dopamine and norepinephrine. The majority of ADHD medications are stimulants, like Ritalin, Concerta, Focalin