The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, the escitalopram drug, fluoxetine (Prozac) Venlafaxine, citalopram, and duloxetine are the first-line treatments for anxiety disorders. Exercise and psychotherapy are also crucial for people suffering from anxiety. Antihistamines such as hydroxyzine (Atarax, Vistaril) are prescribed by a few