Medications For Anxiety Disorder and Depression Medications help many people manage anxiety, but they aren't the only option. Psychotherapy and exercise can be effective treatments. Some antidepressants, like SSRIs (citalopram, Lexapro, fluoxetine, Prozac, paroxetine, Zoloft) also help with anxiety. Other medications, like histamine blockers like Vistaril (hydroxyzine) may also provide